Sevilla lost 2-1 at Real Sociedad, and Sergio Ramos was sent off for the 29th time in his career.
In the 88th minute, the former Real Madrid and Spain defender was sent off for a sliding tackle on Brais Mendez.
The 37-year-old now holds the record for the most red cards in La Liga history with his dismissal on Sunday, at 21.
Jesus Navas, 38, a winger for Sevilla, was dismissed for the first time in his career during a La Liga match after he objected to the call.
More than any other player in the twenty-first century, Ramos has been sent off twenty-one times, more than Rafael Marquez and combined.
After receiving a second yellow card, which the referee changed to a straight red after seeing his pitchside monitor, he was booked on minute eighty-two and sent off six minutes later. Marko Dmitrovic, the goalkeeper for Sevilla, gave Real Sociedad the lead early on with an own goal, and Umar Sadiq then scored a fantastic goal from 25 yards out. Youssef En-Nesyri nearly equalized by hammering a shot against the post, but the Morocco forward was able to pull one back with a deflected header.
Then, following his summertime return to his hometown team, Ramos received his first red card.
After seven league games without a victory, Sevilla dropped to 15th place in the standings, while the home team rose to fifth.